Key issues in the diagnosis and treatment of multiple sclerosis. An overview.

1. A description of MS, covering symptoms and signs, natural history, epidemiology, etiology, and pathology and pathogenesis. 2. A critical analysis of the revised diagnostic criteria for MS that have recently been published by McDonald et al.1 3. A review of the key clinical studies that have been carried out with disease-modifying drugs for MS. 4. A discussion of the use of MRI as a surrogate measure in MS treatment trials, with commentaries on the specific MRI-oriented publications related to Post-Publication Peer Reviews: to this article Submit a response Similar articles found in: Neurology Online PubMed PubMed Citation Search Medline for articles by: O’Connor, P. Alert me when: new articles cite this article Download to Citation Manager